Using modified immune cells to find a cure for HIV
In vivo transformation of chimeric antigen receptor B cells for a functional cure of HIV
This work explores a new way to modify a patient's own immune cells to fight HIV and potentially offer a long-lasting cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11128598 on NIH RePORTER |
What this research studies
Our laboratories are developing a new method to change a patient's B cells, a type of immune cell, so they can produce powerful antibodies against HIV. We use advanced gene-editing tools to teach these B cells to make specific antibodies that can neutralize the virus. These specially modified B cells, called CAR B cells, can then grow, mature, and continuously release these protective antibodies in the body. This approach aims to create a living defense system that can adapt to HIV over time, offering a potential functional cure.
Who could benefit from this research
Good fit: This research is focused on individuals living with HIV who might benefit from a new, long-lasting treatment that could eliminate the virus from their bodies.
Not a fit: Patients without HIV or those with other immune conditions not related to HIV would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could provide a long-term functional cure for HIV, reducing the need for daily medication and adapting to changes in the virus.
How similar studies have performed: While CAR T cell therapies have shown success in cancer, this specific application of CAR B cells for HIV is a novel and largely untested approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Farzan, Michael R. — Boston Children's Hospital
- Study coordinator: Farzan, Michael R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.