Using modified endotracheal tubes to reduce pneumonia in critically ill patients
Official title: Randomized Trial of Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia - Prevent 2 Study
Funded at Duke University · NIH-10657255 · Data updated 2026-11-12
This study is looking at a new kind of breathing tube that might help prevent pneumonia in seriously ill patients on ventilators, and it will compare this new tube to a regular one to see if it makes a difference in keeping patients healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 19, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $743,776 |
| NIH project number | 7R33HL138650-05 |
| Project ID | NIH-10657255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients who require emergency intubation and mechanical ventilation.
✕Less likely to help
Patients who are not critically ill or do not require mechanical ventilation will not benefit from this research.
What this research studies
This research investigates the effectiveness of a new type of endotracheal tube designed to prevent ventilator-associated pneumonia (VAP) in critically ill patients who require mechanical ventilation. The study will compare a modified tube that allows for continuous aspiration of secretions to a standard tube. Patients will be randomly assigned to receive either the new tube or the conventional one during emergency intubation. The goal is to determine if the modified tube can reduce the risk of pneumonia and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of pneumonia in patients on mechanical ventilation, leading to shorter hospital stays and improved long-term health outcomes.
How similar studies have gone: Previous pilot studies have shown promising results with similar modified endotracheal tube designs, indicating potential for success in this larger trial.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Treggiari, Miriam — Duke University
- Study coordinator: Treggiari, Miriam
Related research
Other NIH-funded projects on the same topics.
-
Machine learning to map microbiome changes in ventilator-associated pneumonia
A machine-learning guided study will analyze 16S microbiome data from mechanically ventilated patients to help identify and diagnose ventillator-associated pneumonia earlier.
-
Personalizing antibiotic treatment for pneumonia in patients on ventilators
This study is looking to make the treatment of ventilator-associated pneumonia better by finding ways to personalize how long patients need antibiotics, so they get the right care without extra side effects.
-
Detecting pneumonia in patients on ventilators
This study is working on a new, gentle way to help doctors find out if patients on ventilators have pneumonia by collecting tiny particles from their breath, which could lead to quicker and more accurate treatment for those at risk.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
-
Bacterial Biofilm Therapy with a Human Antibody to Help Antibiotics Work Better
A human antibody drug is being studied to disrupt bacterial biofilms and help standard antibiotics clear infections, especially around implants and catheters, in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.