Using modified endotracheal tubes to reduce pneumonia in critically ill patients
Randomized Trial of Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia - Prevent 2 Study
This study is looking at a new kind of breathing tube that might help prevent pneumonia in seriously ill patients on ventilators, and it will compare this new tube to a regular one to see if it makes a difference in keeping patients healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10657255 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a new type of endotracheal tube designed to prevent ventilator-associated pneumonia (VAP) in critically ill patients who require mechanical ventilation. The study will compare a modified tube that allows for continuous aspiration of secretions to a standard tube. Patients will be randomly assigned to receive either the new tube or the conventional one during emergency intubation. The goal is to determine if the modified tube can reduce the risk of pneumonia and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients who require emergency intubation and mechanical ventilation.
Not a fit: Patients who are not critically ill or do not require mechanical ventilation will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of pneumonia in patients on mechanical ventilation, leading to shorter hospital stays and improved long-term health outcomes.
How similar studies have performed: Previous pilot studies have shown promising results with similar modified endotracheal tube designs, indicating potential for success in this larger trial.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Treggiari, Miriam — Duke University
- Study coordinator: Treggiari, Miriam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.