Using mitofusin activity to improve heart disease treatment
Modulation of Mitofusin Activity to Treat Heart Disease
This study is looking at how adjusting certain proteins in your heart cells can help protect your heart during problems like heart attacks and improve heart function for those with heart failure, with the hope of finding new treatments that make your heart healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10893462 on NIH RePORTER |
What this research studies
This research investigates how modulating the activity of mitofusins, proteins that help control mitochondrial function, can impact heart disease. By manipulating these proteins, the study aims to reduce heart damage during events like heart attacks and improve heart function in patients with heart failure. The approach involves developing specific peptides and small molecules that can either activate or inhibit mitofusins, thereby influencing their role in heart muscle cell metabolism and survival. Patients may benefit from new therapeutic strategies that enhance heart health and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing heart disease or related conditions.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve outcomes for patients with heart disease.
How similar studies have performed: Previous research has shown promising results in manipulating mitofusin activity, indicating potential for success in this novel approach.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Kitsis, Richard N — Albert Einstein College of Medicine
- Study coordinator: Kitsis, Richard N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.