Using mitochondrial DNA to improve early detection and predict recurrence of triple-negative breast cancer in African American women
Mitochondrial DNA in extracellular vesicles for early detection and recurrence prediction in triple negative breast cancer racial disparity
This study is looking at how tiny pieces of DNA from your cells can help find triple-negative breast cancer earlier and predict if it might come back, especially for African American women, so that doctors can offer better screenings and personalized treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project ID | NIH-11138445 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial DNA found in extracellular vesicles to enhance early detection and predict recurrence of triple-negative breast cancer (TNBC), particularly focusing on the disparities faced by African American women. The study aims to identify specific mitochondrial genetic alterations that may contribute to the higher rates of recurrence and metastasis in this population. By analyzing blood samples for these biomarkers, the research seeks to develop a non-invasive method for monitoring cancer progression. Patients may benefit from improved screening and personalized treatment strategies based on their mitochondrial DNA profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with triple-negative breast cancer.
Not a fit: Patients who do not have triple-negative breast cancer or are not of African American descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of triple-negative breast cancer in African American women, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in using mitochondrial DNA as biomarkers in cancer detection, suggesting that this approach may yield valuable insights.
Where this research is happening
Mobile, United States
- University of South Alabama — Mobile, United States (Active)
Researchers
- Principal investigator: Dasgupta, Santanu — University of South Alabama
- Study coordinator: Dasgupta, Santanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.