Using mitochondria-rich microvesicles to improve heart cell energy
Official title: Mitochondria-rich microvesicles for restoration of intracellular bioenergetics
Funded at Stanford University · NIH-11052636 · Data updated 2026-11-12
This study is exploring a new treatment that uses tiny particles from heart cells to help boost energy in damaged heart tissue, which could be helpful for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $386,000 |
| NIH project number | 5R01HL156945-03 |
| Project ID | NIH-11052636 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from heart failure or related cardiac dysfunctions, particularly those with hypertrophic, dilated, or ischemic cardiomyopathy.
✕Less likely to help
Patients with non-cardiac related conditions or those who do not have significant heart dysfunction may not benefit from this research.
What this research studies
This research investigates the use of mitochondria-rich extracellular vesicles (M-EVs) derived from induced pluripotent stem cell (iPSC)-derived cardiomyocytes to restore energy balance in heart cells. The approach focuses on repairing injured heart tissue by enhancing ATP production through mitochondrial transfer and biogenesis. Patients with heart failure may benefit from this innovative therapy, which aims to address the underlying bioenergetic imbalances that contribute to their condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart function and quality of life for patients with heart failure.
How similar studies have gone: Other research has shown promising results using similar approaches with stem cell-derived therapies, indicating potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Yang, Phillip Chung-Ming — Stanford University
- Study coordinator: Yang, Phillip Chung-Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.