Using MIRO1 to stop blood vessel growth after angioplasty
Leveraging the mitochondrial regulator MIRO1 to prevent neointimal hyperplasia
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10984481
This study is looking at a protein called MIRO1 to see if it can help stop the unwanted growth of blood vessels that sometimes happens after angioplasty, with the goal of finding new treatments to keep patients healthier after their procedures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10984481 on ClinicalTrials.gov |
What this research studies
This research investigates how a protein called MIRO1 can help prevent the abnormal growth of blood vessels that often occurs after angioplasty procedures. By understanding how MIRO1 affects the behavior of vascular smooth muscle cells, the researchers aim to develop new therapies that could reduce the risk of restenosis, a common complication following angioplasty. The study will explore the role of MIRO1 in mitochondrial function and its impact on cell signaling, which could lead to innovative treatments for patients undergoing these procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone or are scheduled to undergo angioplasty and are at risk for restenosis.
Not a fit: Patients who have not undergone angioplasty or those with conditions unrelated to vascular occlusive disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the occurrence of restenosis after angioplasty, improving patient outcomes.
How similar studies have performed: While there have been advancements in understanding vascular smooth muscle cell behavior, the specific approach of targeting MIRO1 for preventing restenosis is relatively novel and has not been extensively tested.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRUMBACH, ISABELLA MARIA — UNIVERSITY OF IOWA
- Study coordinator: GRUMBACH, ISABELLA MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.