Using milrinone to prevent complications after heart surgery in very premature infants
1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) – CCC
This study is looking at whether giving a heart medicine called milrinone to tiny babies who are having surgery for a heart condition can help prevent serious problems afterward, making sure they stay healthy and develop well.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10806032 on NIH RePORTER |
What this research studies
This research investigates the use of milrinone, a medication that helps improve heart function, to prevent complications in extremely low birth weight infants who undergo surgery for patent ductus arteriosus (PDA). The study aims to determine if early administration of milrinone can reduce the risk of Post-Ligation Cardiac Syndrome (PLCS), which can lead to serious respiratory and developmental issues. By closely monitoring the infants' heart function and stability after surgery, the researchers hope to establish milrinone's safety and effectiveness in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are extremely low birth weight infants, particularly those born under 1000 grams, who require surgical intervention for patent ductus arteriosus.
Not a fit: Patients who are not extremely premature or do not require surgery for patent ductus arteriosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of serious complications and improve long-term outcomes for extremely premature infants undergoing heart surgery.
How similar studies have performed: Preliminary data from prior observational studies suggest that milrinone may effectively reduce complications in similar patient populations, indicating a promising approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Mcnamara, Patrick J — University of Iowa
- Study coordinator: Mcnamara, Patrick J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.