Using milrinone to prevent complications after heart surgery in very premature infants
Official title: 2/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) - DCC Resubmission
Funded at Research Triangle Institute · NIH-10801049 · Data updated 2026-11-12
This study is looking at whether giving a heart medicine called milrinone can help very premature babies avoid a serious heart problem after they have surgery to fix a blood vessel called the patent ductus arteriosus (PDA).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,172,434 |
| NIH project number | 1U24HL166580-01A1 |
| Project ID | NIH-10801049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are extremely preterm infants, particularly those who are less than 4 weeks old and require surgical closure of a patent ductus arteriosus.
✕Less likely to help
Patients who are not extremely preterm or do not require surgical intervention for patent ductus arteriosus may not benefit from this research.
What this research studies
This research investigates the use of milrinone, a cardiovascular medication, to prevent Post-Ligation Cardiac Syndrome (PLCS) in extremely preterm infants who undergo surgical closure of a patent ductus arteriosus (PDA). The study will involve a multicenter randomized controlled trial where infants will receive either milrinone or a placebo to assess its effectiveness in reducing the incidence of PLCS. By closely monitoring the infants' health outcomes, the research aims to provide clearer evidence on the benefits of milrinone in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of serious complications following heart surgery in extremely preterm infants, leading to better overall health outcomes.
How similar studies have gone: Preliminary data suggest that milrinone may be effective in reducing PLCS, indicating that this approach has potential based on earlier findings, though it has not been rigorously tested in a randomized controlled trial.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Das, Abhik — Research Triangle Institute
- Study coordinator: Das, Abhik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.