Using microRNAs to understand immune responses in gum disease and its links to other health issues
Dominant microRNAs as biomarkers in innate immunity and periodontitis
This study is looking at tiny molecules called microRNAs to see how they affect gum disease and its connection to serious health issues like Alzheimer's and rheumatoid arthritis, with the hope that this could help doctors find better ways to diagnose and treat these conditions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10755604 on NIH RePORTER |
What this research studies
This research investigates the role of specific microRNAs in periodontal disease, which is linked to serious systemic conditions like Alzheimer's disease and rheumatoid arthritis. By examining how these microRNAs behave in response to certain bacteria, the study aims to uncover their potential as biomarkers for diagnosing and understanding these diseases. The research employs both laboratory and animal models to explore the mechanisms by which these microRNAs influence immune responses. Patients may benefit from insights that could lead to improved diagnostic tools and treatment strategies for periodontal disease and its associated health risks.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with periodontal disease or those at risk for related systemic diseases such as Alzheimer's or rheumatoid arthritis.
Not a fit: Patients without periodontal disease or those not at risk for systemic diseases linked to periodontal health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic markers and treatment options for patients suffering from periodontal disease and its related systemic conditions.
How similar studies have performed: Previous research has shown promise in using microRNAs as biomarkers in various diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Lakshmyya, Kesavalu Naidu — University of Florida
- Study coordinator: Lakshmyya, Kesavalu Naidu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.