Using microRNAs to identify and manage obstructive sleep apnea
Official title: MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Funded at University of Pennsylvania · NIH-10880323 · Data updated 2026-11-12
This study is looking at tiny molecules in your blood called microRNAs to see if they can help doctors better identify obstructive sleep apnea, track how well treatments like CPAP are working, and predict how patients will do over time.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $451,657 |
| NIH project number | 5P01HL160471-02 |
| Project ID | NIH-10880323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea or those experiencing symptoms related to the condition.
✕Less likely to help
Patients without obstructive sleep apnea or those who do not exhibit symptoms related to sleep disorders may not benefit from this research.
What this research studies
This research investigates the role of microRNAs as potential biomarkers for obstructive sleep apnea (OSA). By analyzing the expression of microRNAs in blood samples, the study aims to improve the identification of OSA, monitor the effectiveness of treatments like continuous positive airway pressure (CPAP), and predict patient outcomes. The approach involves advanced sequencing techniques and quantitative PCR to assess microRNA levels, which may vary based on the severity of the condition and response to therapy.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnosis and personalized treatment plans for patients with obstructive sleep apnea.
How similar studies have gone: Previous studies have shown promising results in using microRNAs as biomarkers in small sample sizes, indicating potential for success in this research.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Magalang, Ulysses J — University of Pennsylvania
- Study coordinator: Magalang, Ulysses J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.