Using microRNAs to detect and predict Alzheimer's Disease
MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
This study is looking at tiny molecules in the blood called microRNAs to see if they can help spot Alzheimer's disease early and understand how it progresses, making it easier for people to get diagnosed and treated sooner.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11002932 on NIH RePORTER |
What this research studies
This research investigates the potential of microRNAs as reliable biomarkers for the early detection and prognosis of Alzheimer's Disease (AD). By analyzing blood samples from various studies, including the Alzheimer’s Disease Neuroimaging Initiative and others, the researchers aim to identify distinct patterns of circulating microRNA levels that can differentiate between cognitively normal individuals, those with mild cognitive impairment, and dementia patients. The approach focuses on minimally invasive methods to improve accessibility for early diagnosis. If successful, this could lead to more effective preventative and therapeutic strategies for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's Disease, such as those with mild cognitive impairment or a family history of dementia.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a simple blood test for the early detection and monitoring of Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in using biomarkers for Alzheimer's detection, but the specific application of microRNAs in this context is relatively novel.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Delalle, Ivana — Boston University Medical Campus
- Study coordinator: Delalle, Ivana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.