Using microRNA to improve recovery from traumatic brain injury
MicroRNA Therapeutics for Traumatic Brain Injury
This study is looking at how a tiny molecule called miR-125b might help people recover better from traumatic brain injuries by reducing inflammation and protecting brain cells, and it’s designed for anyone who has experienced a TBI.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10769827 on NIH RePORTER |
What this research studies
This research investigates the potential of a specific microRNA, miR-125b, to enhance recovery from traumatic brain injury (TBI) by targeting and inhibiting multiple oncogenes and kinases that are activated after such injuries. The approach involves administering miR-125b to reduce inflammation and neuronal death, which are common consequences of TBI. The study will evaluate the effectiveness of this treatment through various methods, including intravenous and intracerebroventricular delivery of the microRNA. By leveraging insights from cancer research, the goal is to find a novel therapeutic strategy for TBI patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a traumatic brain injury.
Not a fit: Patients with chronic brain injuries or those who do not have a recent history of TBI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for patients suffering from traumatic brain injuries.
How similar studies have performed: Other research has shown promise in using oncogene inhibitors for treating TBI, suggesting that this approach may be viable.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Liu, Da Zhi — University of California at Davis
- Study coordinator: Liu, Da Zhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.