Using microRNA to improve brain health in Alzheimer's Disease
Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology
This study is looking at how a tiny molecule in the brain might be making it harder for the brain to get rid of harmful proteins that contribute to Alzheimer's Disease, and it hopes to find ways to lower this molecule to help improve brain health and slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11012896 on NIH RePORTER |
What this research studies
This research investigates how a specific microRNA affects the brain's ability to clear harmful proteins associated with Alzheimer's Disease. By studying the role of this microRNA in brain immune cells called microglia, the research aims to understand how its elevated levels contribute to the disease's progression. The team will explore ways to reduce this microRNA to enhance the clearance of amyloid-beta, a toxic protein linked to Alzheimer's. This approach could lead to new strategies for alleviating the symptoms and progression of Alzheimer's Disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's Disease or related dementias.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in targeting microRNAs for neurodegenerative diseases, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Amer, Amal O — Ohio State University
- Study coordinator: Amer, Amal O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.