Using microRNA therapy to treat early stage pancreatic cancer
Official title: R21 MPI microRNA directed therapy for treating early stage pancreatic cancer
Funded at University of Florida · NIH-10796987 · Data updated 2026-11-12
This study is looking at a new way to help people with early-stage pancreatic cancer by focusing on tiny molecules called microRNAs that can affect how the cancer grows, with the hope that boosting these microRNAs might slow down the disease and improve treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $203,188 |
| NIH project number | 5R21CA277263-02 |
| Project ID | NIH-10796987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with early stage pancreatic cancer or those with precursor lesions.
✕Less likely to help
Patients with advanced pancreatic cancer or those who do not have pancreatic cancer may not benefit from this research.
What this research studies
This research focuses on developing a new therapy for early stage pancreatic cancer by targeting specific microRNAs that are involved in the disease's progression. The approach involves restoring the levels of certain microRNAs that are reduced during the early stages of pancreatic cancer, which may help in suppressing tumor growth. By studying these microRNAs in laboratory models, the researchers aim to understand their role in cancer development and how they can be used to improve treatment outcomes for patients. The ultimate goal is to enhance early diagnosis and treatment strategies for pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for early stage pancreatic cancer, potentially improving survival rates.
How similar studies have gone: Previous research has shown promise in using microRNA therapies for cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Zhang, Fan — University of Florida
- Study coordinator: Zhang, Fan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.