Using microparticles to deliver anti-inflammatory treatments for spinal cord injury
Official title: Treating Spinal Cord Injury with Mineral Coated Microparticles Releasing Anti-Inflammatory Cytokines
Funded at University of Wisconsin-Madison · NIH-11054680 · Data updated 2026-11-12
This study is exploring a new way to help people with spinal cord injuries by using tiny particles that release special proteins to reduce inflammation, which can help heal the injury and encourage nerve growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | March 15, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $446,238 |
| NIH project number | 5R01NS136564-02 |
| Project ID | NIH-11054680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered a spinal cord injury and are experiencing significant inflammation.
✕Less likely to help
Patients with chronic spinal cord injuries or those who do not exhibit an inflammatory response may not benefit from this research.
What this research studies
This research investigates a novel approach to treat spinal cord injuries by using mineral-coated microparticles that release anti-inflammatory cytokines. The goal is to reduce excessive inflammation that can worsen neural damage following an injury. By delivering these cytokines locally at critical times, the treatment aims to improve healing and promote axon growth. Patients may benefit from a more effective and targeted therapy that addresses the inflammatory response associated with spinal cord injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for patients with spinal cord injuries.
How similar studies have gone: Previous research has shown promise in using localized delivery of anti-inflammatory agents, indicating potential success for this innovative approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Hanna, Amgad S — University of Wisconsin-Madison
- Study coordinator: Hanna, Amgad S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.