Using methotrexate to treat arthritis caused by chikungunya virus
Methotrexate treatment of Arthritis caused by Chikungunya virus (MARCH): A randomized controlled trial of methotrexate versus placebo in the treatment of chronic arthritis after chikungunya infection
['FUNDING_U01'] · GEORGE WASHINGTON UNIVERSITY · NIH-10918064
This study is looking at how well methotrexate, a medicine often used for arthritis, works for people who have chronic arthritis after getting chikungunya virus, and it will help us understand if this treatment can make a difference in reducing their pain and inflammation.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10918064 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of methotrexate, a medication commonly used for arthritis, in treating chronic arthritis that develops after chikungunya virus infection. The study will involve a randomized controlled trial where participants will receive either methotrexate or a placebo for six months. Researchers will assess the impact of the treatment on arthritis severity and inflammation by analyzing synovial tissue samples. The goal is to provide evidence-based recommendations for treating this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have developed chronic arthritis following chikungunya virus infection.
Not a fit: Patients who do not have a history of chikungunya virus infection or those with other forms of arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from chronic arthritis due to chikungunya virus.
How similar studies have performed: While methotrexate is commonly used for various types of arthritis, this specific application for chikungunya-related arthritis is novel and has not been extensively tested in randomized trials.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGE WASHINGTON UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, AILEEN — GEORGE WASHINGTON UNIVERSITY
- Study coordinator: CHANG, AILEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.