Using metformin to slow down abdominal aortic aneurysm progression
The LIMIting AAA with meTformin (LIMIT) Trial
This study is looking at whether the diabetes medication metformin can help slow down the growth of abdominal aortic aneurysms in people who don’t have diabetes, and it’s for anyone interested in finding out if this treatment could be beneficial for their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10885082 on NIH RePORTER |
What this research studies
This research investigates whether metformin, a common diabetes medication, can help slow the progression of abdominal aortic aneurysms (AAAs) in non-diabetic patients. The study will assess the safety and tolerability of metformin through regular quality of life surveys and medical examinations. Participants will be monitored for compliance and any potential side effects, with the goal of determining if metformin can effectively reduce the risk of AAA enlargement and rupture.
Who could benefit from this research
Good fit: Ideal candidates for this research are non-diabetic adults diagnosed with abdominal aortic aneurysms.
Not a fit: Patients with diabetes or those who do not have abdominal aortic aneurysms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new non-surgical treatment option for patients with abdominal aortic aneurysms, potentially reducing the risk of life-threatening complications.
How similar studies have performed: Previous observational studies have suggested that metformin may reduce AAA progression, but this research aims to rigorously test that hypothesis in a controlled setting.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Dalman, Ronald L — Stanford University
- Study coordinator: Dalman, Ronald L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.