Using Metformin to Reduce Stroke Risk in Smokers
Repurposing Metformin to Offset Stroke Risk and Injury in Comorbid Populations of Smokers
This study is looking at whether the diabetes drug metformin can help protect the brains of people who smoke or use e-cigarettes from stroke and injury by reducing damage caused by tobacco smoke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10848237 on NIH RePORTER |
What this research studies
This research investigates how the diabetes medication metformin can be repurposed to protect against stroke risk and brain injury in individuals who smoke or use e-cigarettes. The study focuses on understanding the effects of oxidative stress and inflammation caused by tobacco smoke on the blood-brain barrier, which is crucial for brain health. By examining both preclinical and clinical data, the researchers aim to determine if metformin can mitigate these harmful effects and improve outcomes for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are smokers or e-cigarette users who may be at increased risk for stroke and related brain injuries.
Not a fit: Patients who do not smoke or use e-cigarettes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for reducing stroke risk and brain injury in smokers.
How similar studies have performed: Preliminary studies have shown promising results in using metformin for similar protective effects, indicating potential for success in this approach.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Abbruscato, Thomas J — Texas Tech University Health Scis Center
- Study coordinator: Abbruscato, Thomas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.