Using metformin to help older adults recover muscle strength and function
Official title: Leveraging senotherapeutic properties of metformin to improve collagen remodeling during muscle regrowth in older adults
Funded at University of Utah · NIH-11099672 · Data updated 2026-11-12
This study is looking at how the diabetes medication metformin might help older adults recover their muscle strength after being inactive, by improving the way their body heals and rebuilds muscle.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $610,209 |
| NIH project number | 5R01AG086328-02 |
| Project ID | NIH-11099672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have experienced muscle disuse or weakness.
✕Less likely to help
Patients who are younger or have no history of muscle disuse or related impairments may not benefit from this research.
What this research studies
This research investigates how metformin, a common diabetes medication, can improve muscle recovery in older adults after periods of inactivity. The study focuses on the cellular processes involved in muscle regrowth, particularly how metformin may enhance the function of immune cells and reduce harmful cellular aging effects. By targeting specific cellular mechanisms, the research aims to promote better collagen remodeling and overall muscle health, potentially leading to improved strength and reduced risk of falls in older individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle recovery and prevent disability in older adults.
How similar studies have gone: Previous research has shown promising results using metformin for muscle health, but this specific approach to muscle recovery in older adults is novel.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Drummond, Micah J — University of Utah
- Study coordinator: Drummond, Micah J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.