Using metal-titanates to fight tooth decay by targeting harmful bacteria
Metal-titanates, novel anti-caries catalysts for modulating the virulence of cariogenic biofilms
This study is looking at a special material that could help fight the bad bacteria that cause cavities in your teeth, while keeping the good bacteria safe, to improve dental treatments and help prevent tooth decay.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10918105 on NIH RePORTER |
What this research studies
This research investigates the use of metal-titanates as catalysts to produce reactive oxygen species that can inhibit harmful bacteria responsible for dental caries, particularly Streptococcus mutans. By leveraging the properties of these materials, the study aims to enhance the natural defense mechanisms of the oral microbiome against caries-causing pathogens. The approach involves examining how these catalysts can selectively target and reduce the virulence of cariogenic biofilms while preserving beneficial bacteria. Patients may benefit from improved dental treatments that could prevent tooth decay more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of dental caries or those at high risk for developing tooth decay.
Not a fit: Patients who do not have dental caries or are not at risk for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly reduce the incidence of dental caries.
How similar studies have performed: Previous research has shown promise in using similar catalytic approaches to target oral pathogens, indicating potential for success in this novel application.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Huang, Xuelian — University of Washington
- Study coordinator: Huang, Xuelian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.