Using metabolomics to understand aging mechanisms
Official title: Metabolomics clocks as a tool to explore mechanisms of aging
Funded at Tufts University Boston · NIH-10977897 · Data updated 2026-11-12
This study is looking at how tiny molecules in our bodies can help us understand aging and age-related health problems, using fruit flies to see how diet and genes affect aging, with the hope of finding ways to help people age healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $592,507 |
| NIH project number | 1R01AG082696-01A1 |
| Project ID | NIH-10977897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in understanding the biological aspects of aging and those who may be experiencing age-related health issues.
✕Less likely to help
Patients with acute conditions unrelated to aging or those who are not interested in the biological mechanisms of aging may not benefit from this research.
What this research studies
This research investigates how metabolomics, the study of small molecules in biological systems, can serve as a tool to understand the mechanisms of aging. By analyzing metabolome profiles, the research aims to identify biomarkers that predict aging and age-related health issues. The approach involves using model organisms like Drosophila to explore how metabolites influence aging through dietary and genetic interventions. This could provide insights into the biological processes that underlie aging and potentially lead to new strategies for promoting healthier aging.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers for aging, helping to improve health outcomes and longevity for patients.
How similar studies have gone: Previous research has shown promise in using metabolomics to study aging, indicating that this approach could yield valuable insights.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Promislow, Daniel Edward — Tufts University Boston
- Study coordinator: Promislow, Daniel Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.