Using men's social networks to increase HIV self-testing and PrEP use

Harnessing male peer networks to enhance engagement with HIV prevention: A largescale cluster randomized trial to increase HIV self-testing and PrEP uptake

NIH-funded research Stellenbosch University · NIH-11419039

This project offers HIV self-test kits through men's social networks with phone support to help men in eastern Zimbabwe get tested and start PrEP.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionStellenbosch University NIH-funded
Lab location1 site (Stellenbosch, SOUTH AFRICA)
Project IDNIH-11419039 on NIH RePORTER

What this research studies

You would be reached through male peer networks where friends distribute HIV self-test kits and encourage follow-up. Some communities are randomly chosen to receive the peer distribution plus phone-based support and improved information about HIV risk, while other communities continue with usual services. About 3,591 men across 44 community clusters will be followed for six months using data from the long-running Manicaland cohort to see who starts PrEP. The study tracks HIV testing, PrEP initiation, and related behaviors to learn whether this approach helps more men access prevention.

Who could benefit from this research

Good fit: Ideal participants are men living in the participating communities of eastern Zimbabwe who are HIV-negative or unsure of their status and are reachable by phone.

Not a fit: People who already know they are HIV-positive, are on effective HIV treatment, or who live outside the study communities are unlikely to benefit from this program.

Why it matters

Potential benefit: If successful, more men could learn their HIV status and start PrEP, reducing HIV risk for themselves and their partners.

How similar studies have performed: Previous work in sub-Saharan Africa shows peer-distributed HIV self-testing is feasible and acceptable, though using it specifically to increase PrEP starts is less established.

Where this research is happening

Stellenbosch, SOUTH AFRICA

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.