Using men's social networks to boost HIV self-testing and PrEP uptake

Harnessing male peer networks to enhance engagement with HIV prevention: A largescale cluster randomized trial to increase HIV self-testing and PrEP uptake

NIH-funded research Stellenbosch University · NIH-11400627

This project helps men in eastern Zimbabwe get HIV self-test kits and phone-based support from male peers to increase starting HIV prevention medicine (PrEP).

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionStellenbosch University NIH-funded
Lab location1 site (Stellenbosch, SOUTH AFRICA)
Project IDNIH-11400627 on NIH RePORTER

What this research studies

If I join, the team will work through groups of men in local communities and train peer leaders to distribute HIV self-test kits and offer phone support. Half the communities will get this peer-distribution plus phone help while the other half continue usual services, and about 3,591 men will be followed for six months. The researchers will use existing Manicaland surveillance data and local clinics that now provide PrEP to link testing to clinic referrals. They will compare how many men start PrEP in the peer-supported communities versus the usual-care communities.

Who could benefit from this research

Good fit: Men living in the study communities in eastern Zimbabwe who are sexually active and not currently on PrEP or known to be HIV-positive are the ideal candidates.

Not a fit: People who already have HIV, are already taking PrEP, or live outside the study area are unlikely to receive direct benefit from this project.

Why it matters

Potential benefit: If successful, more men may learn their HIV status quickly and be more likely to start PrEP, lowering their risk of HIV and reducing new infections in partners.

How similar studies have performed: Previous work in sub-Saharan Africa has shown peer distribution of HIV self-tests is feasible and increases testing, but evidence that this reliably leads to higher PrEP uptake is still limited.

Where this research is happening

Stellenbosch, SOUTH AFRICA

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.