Using medication to help adolescents with severe obesity maintain weight loss
Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents with Severe Obesity
This study is looking at how a combination of two medications can help teenagers with severe obesity keep off the weight they’ve lost by tackling the biological changes that make it hard to maintain weight loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10812384 on NIH RePORTER |
What this research studies
This research investigates how pharmacotherapy can help adolescents with severe obesity maintain their weight loss over the long term. It focuses on understanding the biological changes that occur after weight loss, which often lead to weight regain, such as increased appetite and decreased energy expenditure. The study will explore the effectiveness of a combination medication, phentermine and topiramate, which may help counteract these biological adaptations and support sustained weight management. Participants will be involved in a controlled clinical trial to assess the safety and efficacy of this treatment approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents with severe obesity who have recently lost weight and are at risk of regaining it.
Not a fit: Patients who are not adolescents or those who do not have severe obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new effective treatment option for adolescents struggling to maintain weight loss.
How similar studies have performed: Other research has shown promise in using pharmacotherapy for weight management, but this specific combination in adolescents is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Kelly, Aaron S — University of Minnesota
- Study coordinator: Kelly, Aaron S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.