Using MDMA to improve social interactions in people with schizophrenia

MDMA as a Treatment for Social Deficits in Schizophrenia

['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10932872

This study is looking at whether MDMA can help people with schizophrenia feel more connected and engaged socially, by giving different doses of the substance in a safe setting and seeing how it affects their social behavior.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded)
Locations1 site (LOS ANGELES, UNITED STATES)
Trial IDNIH-10932872 on ClinicalTrials.gov

What this research studies

This research investigates the potential of MDMA, a substance known for its ability to enhance feelings of empathy and social connection, as a treatment for social deficits in individuals with schizophrenia. The study will involve administering varying doses of MDMA to participants in a controlled setting to assess its effects on social motivation and engagement. By focusing on the unique properties of MDMA, the research aims to explore a novel approach to addressing a significant and often untreated symptom of schizophrenia. Participants will be closely monitored throughout the trial to evaluate changes in their social behavior and motivation.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who experience significant social deficits.

Not a fit: Patients who do not have schizophrenia or those whose social deficits are not a primary concern may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a new treatment option for improving social motivation in patients with schizophrenia, potentially enhancing their quality of life.

How similar studies have performed: Previous research has shown promise for MDMA in treating other psychiatric conditions, suggesting potential for success in this novel application.

Where this research is happening

LOS ANGELES, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.