Using mathematical models to manage BK virus infection in kidney transplant patients
Mathematical modeling for optimal control of BK virus infection in kidney transplant recipients
This study is working on a smart tool to help doctors create personalized treatment plans for kidney transplant patients dealing with BK virus infections, so they can find the right balance between preventing organ rejection and managing their immune system.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10861036 on NIH RePORTER |
What this research studies
This research focuses on developing mathematical models to optimize the management of BK virus (BKV) infection in kidney transplant recipients. It aims to create personalized treatment plans that balance the need for immunosuppression with the risk of organ rejection. By analyzing longitudinal data from kidney transplant patients, the researchers will calibrate and validate these models to improve patient outcomes. The ultimate goal is to provide a software-guided approach to help clinicians make informed decisions about immunosuppression levels for individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are kidney transplant recipients who are experiencing BK virus viremia.
Not a fit: Patients who have not undergone kidney transplantation or those without BK virus infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective management of BK virus infections, potentially preserving kidney function and reducing the risk of organ loss in transplant recipients.
How similar studies have performed: Other research has shown promise in using mathematical modeling for managing infectious diseases, suggesting that this approach could be effective for BK virus management as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Mccarthy, Janice Marie — Duke University
- Study coordinator: Mccarthy, Janice Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.