Using Magnetic Particle Imaging to track T cells in treating Lewy Body Dementia
Magnetic Particle Imaging to Track T Cells in Molecular Guided T Cell Therapy for LBDs
This study is looking at a new way to track special immune cells called T cells in people with Lewy Body Dementia, using a technique that lets us see how these cells move and work in the brain, which could help us understand if this therapy is effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10937192 on NIH RePORTER |
What this research studies
This research investigates the use of Magnetic Particle Imaging (MPI) to non-invasively track T cells that are part of a new therapy for Lewy Body Dementia (LBD). By labeling these T cells with MPI tracers, researchers aim to monitor their movement and effectiveness in the brain. The study will also explore the relationship between the tracking signals and the presence of α-synuclein, a protein associated with LBD, to better understand how well the therapy works. This approach could provide valuable insights into the potential of T cell therapies for neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy Body Dementia who may benefit from innovative T cell therapies.
Not a fit: Patients with other forms of dementia or those not diagnosed with Lewy Body Dementia may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Lewy Body Dementia by improving the understanding of T cell therapy dynamics.
How similar studies have performed: Previous research has shown promise in using similar imaging techniques for tracking therapeutic cells in cancer treatments, suggesting potential for success in this novel application.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Rinaldi-Ramos, Carlos M — University of Florida
- Study coordinator: Rinaldi-Ramos, Carlos M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.