Using magnesium to protect the brain after cardiac arrest
Official title: Neuroprotection following cardiac arrest: A Randomized Control Trial of Magnesium
Funded at New York University School of Medicine · NIH-10914294 · Data updated 2026-11-12
This study is looking at whether magnesium can help protect the brain and improve recovery for people who have survived a cardiac arrest, by reducing brain injury caused by a lack of blood flow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $254,250 |
| NIH project number | 5R34HL166859-02 |
| Project ID | NIH-10914294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a cardiac arrest and are receiving post-resuscitation care.
✕Less likely to help
Patients who have not experienced cardiac arrest or those with contraindications to magnesium treatment may not benefit from this research.
What this research studies
This research investigates the potential of magnesium as a neuroprotective agent for patients who have experienced cardiac arrest. It aims to understand how magnesium can help reduce brain injury caused by the lack of blood flow and subsequent inflammation when blood circulation is restored. The study will involve a randomized control trial to gather data on the safety and effectiveness of magnesium treatment in improving neurological outcomes for survivors of cardiac arrest. Patients will be monitored closely to assess the impact of magnesium on their recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better neurological recovery for patients who have suffered cardiac arrest.
How similar studies have gone: Previous small-scale studies have shown promising results for magnesium in improving outcomes after cardiac arrest, indicating potential for success in this larger trial.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Parnia, Sam — New York University School of Medicine
- Study coordinator: Parnia, Sam
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.