Using machine learning to understand how HIV hides in the body
MOIR - Machine Learning and Modeling Core
['FUNDING_P01'] · EMORY UNIVERSITY · NIH-11523467
This project uses computer learning tools on patient samples to find biological and environmental factors that help HIV persist in people on ART.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11523467 on ClinicalTrials.gov |
What this research studies
Researchers will combine data from several linked projects—including blood tests, microbiome and metabolite profiles, and immune measurements—into a single analysis using advanced computer models. The core team will use machine learning to look for patterns that link microbes, metabolites, and immune changes to the size and behavior of the HIV reservoir. Models will connect how these factors alter immune gene activity and epigenetics in different cell types. The goal is to generate clear clues about why HIV remains after standard therapy and which targets could be tested in future clinical approaches.
Who could benefit from this research
Good fit: Ideal participants are people living with HIV who are on antiretroviral therapy and can give blood or other samples for multi-omic testing, or who are enrolled in one of the linked projects.
Not a fit: People who do not have HIV, are not on ART, or who cannot provide samples or join related projects are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could point to new ways to shrink or eliminate the HIV reservoir and guide treatments tailored to people living with HIV.
How similar studies have performed: Applying machine learning to multi-omics and HIV reservoir data is a promising but still emerging approach with some early encouraging results and many unanswered questions.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARMA, ASHISH ARUNKUMAR — EMORY UNIVERSITY
- Study coordinator: SHARMA, ASHISH ARUNKUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus