Using low-frequency brain stimulation to control seizures
Low-frequency stimulation of fiber tracts to control seizures
This study is exploring a new way to help people with epilepsy who haven't found relief from current treatments by using gentle brain stimulation to see if it can reduce their seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10745981 on NIH RePORTER |
What this research studies
This research investigates a novel approach to managing epilepsy by using low-frequency stimulation of specific brain fiber tracts, particularly the corpus callosum. The study aims to determine if this method can effectively reduce seizures in patients who do not respond to current treatments. By comparing this technique to existing high-frequency stimulation methods, the research seeks to understand the mechanisms behind seizure control and improve outcomes for patients with focal epilepsy. The research involves both acute and chronic models to assess the effectiveness of this stimulation approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with focal epilepsy, particularly those who have not responded to conventional seizure medications.
Not a fit: Patients with generalized epilepsy or those whose seizures are well-controlled with existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients with epilepsy who currently have uncontrolled seizures.
How similar studies have performed: Previous studies have shown success with similar low-frequency stimulation approaches in animal models, but this specific application in humans is novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Durand, Dominique M — Case Western Reserve University
- Study coordinator: Durand, Dominique M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.