Using low doses of interleukin-2 to improve immune response in Crohn's disease
Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs Disease
This study is looking at whether a low dose of a medicine called interleukin-2 can help boost the immune system's regulatory cells in people with Crohn's disease, especially for those who haven't had good results with other treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10892193 on NIH RePORTER |
What this research studies
This research investigates the use of low-dose interleukin-2 (IL-2) to enhance the function of regulatory T cells (Tregs) in patients with Crohn's disease, a type of inflammatory bowel disease. By selectively expanding Tregs, which help regulate the immune system, the study aims to improve treatment outcomes for patients who do not respond well to existing therapies. The approach is based on previous findings that low-dose IL-2 is safe and effective in other conditions, and it will involve clinical trials to assess its impact on Crohn's disease symptoms and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who have not achieved satisfactory results from current treatments.
Not a fit: Patients with other forms of inflammatory bowel disease, such as ulcerative colitis, or those who are not diagnosed with Crohn's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients with Crohn's disease, potentially improving their quality of life and disease management.
How similar studies have performed: Previous studies have shown that low-dose IL-2 can effectively expand Tregs and has been safe in other clinical settings, suggesting a promising avenue for treatment in Crohn's disease.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Snapper, Scott B — Boston Children's Hospital
- Study coordinator: Snapper, Scott B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.