Using low-dose aspirin early in pregnancy to prevent preeclampsia and miscarriage
Official title: Early Double Low-Dose Aspirin to Reduce Preeclampsia and Miscarriage: a Global Approach RCT
Funded at University of Pennsylvania · NIH-10901882 · Data updated 2026-11-12
This study is looking at whether taking a low dose of aspirin right after you find out you're pregnant can help prevent serious issues like preeclampsia and miscarriage, and it's for anyone who just got a positive pregnancy test.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $680,699 |
| NIH project number | 5R01HD112308-02 |
| Project ID | NIH-10901882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently confirmed a pregnancy and are within the first trimester.
✕Less likely to help
Patients who are not pregnant or those who have contraindications to aspirin use may not benefit from this research.
What this research studies
This research investigates the effects of starting low-dose aspirin therapy at the very beginning of pregnancy to see if it can help prevent serious complications like preeclampsia and miscarriage. Participants will be recruited through early pregnancy tests, allowing for timely intervention. The study will compare the outcomes of those taking a higher dose of aspirin daily from the first positive pregnancy test against those who do not. This approach aims to gather high-quality evidence on the benefits of early aspirin use in a diverse group of pregnant individuals.
Why it matters
Potential benefit: If successful, this research could significantly reduce the rates of preeclampsia and miscarriage, improving outcomes for pregnant individuals and their babies.
How similar studies have gone: Previous research has shown that aspirin can be beneficial in preventing preeclampsia when started later in pregnancy, but this approach of early initiation with a higher dose is novel.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Schisterman, Enrique F. — University of Pennsylvania
- Study coordinator: Schisterman, Enrique F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.