Using liquid biopsies to study how a ketogenic diet affects brain health in mild cognitive impairment
Liquid biopsies to evaluate the effect of a ketogenic diet on molecular circuitries associated with mild cognitive impairment
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11030759
This study is looking at how tiny particles in your blood can help track changes in the brain for people with early signs of Alzheimer's, and it will explore whether a special diet can improve brain function for those with mild memory issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11030759 on ClinicalTrials.gov |
What this research studies
This research investigates the role of small extracellular vesicles, or exosomes, as liquid biopsies to monitor molecular changes in the brain associated with Alzheimer's disease and related dementias. The study focuses on the effects of a Modified Mediterranean-Ketogenic Diet (MMKD) on individuals with amnestic mild cognitive impairment (aMCI). Participants will undergo various assessments, including cognitive testing, brain imaging, and analysis of biomarkers, to evaluate the diet's impact on brain function and identify those who may benefit most from this dietary intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with amnestic mild cognitive impairment.
Not a fit: Patients without mild cognitive impairment or those who are not interested in dietary interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve cognitive health and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results for ketogenic diets in improving cognitive function in individuals with mild cognitive impairment, suggesting potential for success in this research.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEEP, GAGAN — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: DEEP, GAGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.