Using liposomal azithromycin to reduce heart inflammation
Official title: Liposomal azithromycin to treat cardiac inflammation
Funded at University of Kentucky · NIH-11040627 · Data updated 2026-11-12
This study is looking at a special version of the antibiotic azithromycin to see if it can help your heart heal better after a heart attack by calming down inflammation and helping your immune system work in a positive way.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | March 18, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $542,094 |
| NIH project number | 1R61HL177474-01 |
| Project ID | NIH-11040627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction or have other forms of cardiac inflammation.
✕Less likely to help
Patients with stable coronary artery disease who have not experienced recent heart events may not benefit from this research.
What this research studies
This research investigates the use of a special formulation of azithromycin, an antibiotic, to help reduce inflammation in the heart after events like heart attacks. The study focuses on how this treatment can change the behavior of immune cells to promote healing rather than causing further damage. By targeting the inflammatory response that follows myocardial infarctions, the research aims to improve heart recovery and prevent complications. Patients may be monitored for changes in heart function and inflammation markers during the treatment process.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that significantly improves recovery and outcomes for patients with heart inflammation after heart attacks.
How similar studies have gone: Previous research has shown promise in using similar approaches to modulate inflammation in cardiac conditions, suggesting potential for success in this area.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Venditto, Vincent Joseph — University of Kentucky
- Study coordinator: Venditto, Vincent Joseph
Related research
Other NIH-funded projects on the same topics.
-
East Palestine health impact study following train derailment
A community-engaged study in East Palestine will follow residents to understand health symptoms, exposure markers, and air quality after a major train derailment.
-
Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
A research team is studying why some young people develop a severe form of gum disease called Grade C periodontitis and how genetics and bacteria like Aa may contribute.
-
Regulation of exon junction complex in cancer biology
This grant studies how a key molecular complex that controls RNA processing acts in cancer, with the aim of understanding how it contributes to cancer cell behavior.
-
Alcohol use and suicidal thoughts: how decision-making affects risk
This project looks at how acute alcohol use and people’s decision-making patterns relate to suicidal thoughts and behaviors in adults.
-
Kentucky workplace health surveillance program improving safety for workers
A national institute-funded program is supporting Kentucky to monitor and improve safety and health at work for better protection of workers.
-
Gabapentin use in older adults and related health outcomes
This project will look at how gabapentin is used by older adults and whether that use is linked to health outcomes using Medicare data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.