Using light to monitor blood flow in the brains of children with sickle cell disease
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease
This study is working on a simple and affordable way to check brain health in kids with sickle cell disease by looking at blood flow and oxygen levels, helping to spot hidden brain injuries early so they can get the care they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10763799 on NIH RePORTER |
What this research studies
This research focuses on developing a low-cost tool to monitor brain health in children with sickle cell disease (SCD) by assessing blood flow and oxygen levels. It aims to identify silent cerebral infarctions, which are hidden brain injuries that can lead to cognitive issues and strokes. By using diffuse optical spectroscopies, the study will measure microvascular blood flow and vascular reactivity, providing critical information for timely interventions. The goal is to create a routine screening method that is safe and accessible for young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with sickle cell disease, particularly those under the age of 15.
Not a fit: Patients with other forms of anemia or those who do not have sickle cell disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and prevention of brain injuries in children with sickle cell disease, improving their cognitive outcomes and quality of life.
How similar studies have performed: Previous studies have shown success in using imaging techniques to monitor brain health in sickle cell patients, but this approach using diffuse optical spectroscopies is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Buckley, Erin Mcguire — Emory University
- Study coordinator: Buckley, Erin Mcguire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.