Using light to control gene expression and cell behavior in mammals
Multiplexed Optogenetic Control of Mammalian Genome and Transcriptome using Recombinases and Cas13
This study is exploring how we can use different colors of light to control how genes work in muscle cells, which could help us understand how to guide these cells to become either muscle or bone, making it easier to develop new treatments for conditions related to these tissues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884216 on NIH RePORTER |
What this research studies
This research investigates how light can be used to control gene expression and cellular behavior in mammalian cells. By developing advanced optogenetic tools that respond to different wavelengths of light, the project aims to create a system that can precisely regulate multiple genes simultaneously. The approach involves using genetically encoded proteins that can be activated by light to either permanently alter gene expression or modulate it reversibly. This innovative method will be tested in muscle cells that can differentiate into bone or muscle cells, allowing researchers to explore how light influences cell fate decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from targeted gene therapy or cellular reprogramming.
Not a fit: Patients with conditions unrelated to gene expression or cellular behavior may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that harness light to control gene expression in various diseases.
How similar studies have performed: Previous research has shown promise in using optogenetic tools for gene regulation, indicating that this approach could be effective.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Tous, Cristina — Boston University (Charles River Campus)
- Study coordinator: Tous, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.