Using light to control gene activity in blood stem cells
Confocal illumination system to apply optogenetic tools for hematopoietic stem cell biology with single cell resolution
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11099228
This study is exploring new ways to control how blood stem cells grow and develop, which could help scientists learn more about blood-related conditions and lead to better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11099228 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced optogenetic tools that allow scientists to control gene expression in hematopoietic stem cells with high precision. By utilizing a confocal illumination system, the researchers aim to manipulate these cells at a single-cell level, which could lead to a better understanding of how blood cells grow and differentiate. The approach involves using molecular genetic techniques to uncover the mechanisms behind cellular proliferation and differentiation. Patients may benefit from insights gained through this research, which could inform future therapies for blood-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with blood disorders or conditions related to hematopoietic stem cells.
Not a fit: Patients with non-hematological conditions or those not affected by blood cell disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating blood disorders by enhancing our understanding of stem cell behavior.
How similar studies have performed: Other research has shown promise in using optogenetic tools for cellular control, indicating that this approach could be effective.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAZAWA, MASAYUKI — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: YAZAWA, MASAYUKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.