Using Letrozole to treat uterine fibroids
Official title: Letrozole for Treatment of Uterine Fibroids: A randomized, placebo-controlled trial
Funded at University of California, San Francisco · NIH-10912014 · Data updated 2026-11-12
This study is looking at how well Letrozole, a medication that lowers estrogen, can help women with uterine fibroids by easing symptoms like heavy bleeding and pelvic pain, and it's for those who want to explore a non-surgical option.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $671,122 |
| NIH project number | 5R01HD112465-02 |
| Project ID | NIH-10912014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premenopausal women diagnosed with uterine fibroids who experience significant symptoms.
✕Less likely to help
Patients who have already undergone surgery for fibroids or those who are postmenopausal may not benefit from this research.
What this research studies
This research investigates the effectiveness of Letrozole, a medication that inhibits estrogen production, in treating uterine fibroids, which are common tumors affecting many women. The study involves a randomized, placebo-controlled trial where participants will receive either Letrozole or a placebo to assess its impact on fibroid symptoms such as heavy bleeding and pelvic pain. By focusing on a non-surgical treatment option, the research aims to provide an alternative for women who prefer to avoid major surgery and its associated recovery time. Participants will be monitored for changes in fibroid size and symptom relief throughout the trial period.
Why it matters
Potential benefit: If successful, this research could provide a new, effective non-surgical treatment option for women suffering from uterine fibroids.
How similar studies have gone: Previous research has shown promise in using aromatase inhibitors for similar conditions, indicating potential for success in this approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Jacoby, Vanessa — University of California, San Francisco
- Study coordinator: Jacoby, Vanessa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.