Using Lactobacillus to reduce gut issues caused by alcohol consumption
Official title: Lactobacillus-vectored Alkaline Phosphatase to Mitigate Alcohol-induced Leaky Gut and LPS Endotoxin Load in the Gut
Funded at Biomedit LLC · NIH-11061695 · Data updated 2026-11-12
This study is looking at how a special type of good bacteria can help protect your gut from the harmful effects of alcohol, with the hope that it can improve gut health and reduce inflammation for people who drink regularly.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biomedit LLC NIH-funded |
| Lab location | 1 site (Fishers, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $131,654 |
| NIH project number | 1R43AA032131-01 |
| Project ID | NIH-11061695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol regularly and experience gut-related health issues.
✕Less likely to help
Patients who do not consume alcohol or have no gut health issues may not benefit from this research.
What this research studies
This research investigates how a specific strain of Lactobacillus can deliver alkaline phosphatase to the gut, aiming to reduce the harmful effects of alcohol on gut health. Chronic alcohol consumption can lead to increased intestinal permeability and inflammation, which this approach seeks to mitigate. By utilizing a proprietary drug delivery technology, the study aims to enhance the bioavailability of alkaline phosphatase, making it more effective in detoxifying harmful substances in the gut. Patients may benefit from improved gut health and reduced systemic inflammation associated with alcohol use.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and reduce inflammation for individuals struggling with alcohol-related issues.
How similar studies have gone: Previous research has shown promise in using similar approaches to improve gut health and reduce inflammation, suggesting potential for success in this novel application.
Where this research is happening
-
Biomedit LLC
Fishers, United States Active
Researchers
- Principal investigator: Gangaiah, Dharanesh — Biomedit LLC
- Study coordinator: Gangaiah, Dharanesh
Related research
Other NIH-funded projects on the same topics.
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Engineered probiotic to reduce alcohol-related leaky gut and endotoxin
An engineered Lactobacillus that delivers an enzyme to the gut to help reduce alcohol-related leakiness and toxic bacterial endotoxin in people with alcoholic liver disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.