Using Lactobacillus to reduce gut issues caused by alcohol consumption
Lactobacillus-vectored Alkaline Phosphatase to Mitigate Alcohol-induced Leaky Gut and LPS Endotoxin Load in the Gut
This study is looking at how a special type of good bacteria can help protect your gut from the harmful effects of alcohol, with the hope that it can improve gut health and reduce inflammation for people who drink regularly.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biomedit LLC NIH-funded |
| Lab location | 1 site (Fishers, United States) |
| Project ID | NIH-11061695 on NIH RePORTER |
What this research studies
This research investigates how a specific strain of Lactobacillus can deliver alkaline phosphatase to the gut, aiming to reduce the harmful effects of alcohol on gut health. Chronic alcohol consumption can lead to increased intestinal permeability and inflammation, which this approach seeks to mitigate. By utilizing a proprietary drug delivery technology, the study aims to enhance the bioavailability of alkaline phosphatase, making it more effective in detoxifying harmful substances in the gut. Patients may benefit from improved gut health and reduced systemic inflammation associated with alcohol use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume alcohol regularly and experience gut-related health issues.
Not a fit: Patients who do not consume alcohol or have no gut health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and reduce inflammation for individuals struggling with alcohol-related issues.
How similar studies have performed: Previous research has shown promise in using similar approaches to improve gut health and reduce inflammation, suggesting potential for success in this novel application.
Where this research is happening
Fishers, United States
- Biomedit LLC — Fishers, United States (Active)
Researchers
- Principal investigator: Gangaiah, Dharanesh — Biomedit LLC
- Study coordinator: Gangaiah, Dharanesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.