Using Lactobacillus plantarum to reduce inflammation in new onset Type 1 diabetes
Reducing innate inflammation in new onset T1D with Lactobacillus plantarum
This study is exploring how a friendly bacteria called Lactobacillus plantarum might help lower inflammation in kids who have just been diagnosed with Type 1 diabetes, to see if changing their gut bacteria can improve their health and slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10850641 on NIH RePORTER |
What this research studies
This research investigates how Lactobacillus plantarum, a type of beneficial bacteria, can help reduce inflammation in children newly diagnosed with Type 1 diabetes (T1D). The study looks at the relationship between inflammation and the immune response that leads to T1D, focusing on how modifying gut bacteria may improve the condition. By examining both human subjects and a rat model, the researchers aim to understand how these changes can prevent the progression of T1D. Patients may be monitored for changes in their immune response and overall health as part of the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have recently been diagnosed with Type 1 diabetes.
Not a fit: Patients who are not newly diagnosed with Type 1 diabetes or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Type 1 diabetes in children.
How similar studies have performed: Previous studies have shown promise in using microbiota modulation to influence autoimmune conditions, suggesting potential success for this approach.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Hessner, Martin J — Medical College of Wisconsin
- Study coordinator: Hessner, Martin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.