Using L-selectin shedding to reduce damage after spinal cord injury
L-selectin shedding as a novel therapeutic strategy to mitigate acute secondary damage after spinal cord injury
This study is looking at how a specific immune cell receptor called L-selectin affects inflammation and recovery after spinal cord injuries, and it’s testing an approved medication, diclofenac, to see if it can help reduce harmful inflammation and improve healing for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10868456 on NIH RePORTER |
What this research studies
This research investigates how L-selectin, a receptor on immune cells, contributes to inflammation and secondary damage following spinal cord injury (SCI). By using diclofenac, an FDA-approved medication, the study aims to promote L-selectin shedding, which may help reduce harmful immune responses and improve recovery outcomes. The research will explore the mechanisms by which L-selectin affects neutrophil activity, the most common immune cells involved in the inflammatory response after SCI. Patients may benefit from this approach if it leads to new therapeutic strategies for managing inflammation after spinal cord injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a spinal cord injury and are within a specific time frame for treatment.
Not a fit: Patients with chronic spinal cord injuries or those who are not eligible for intravenous treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that minimize secondary damage and enhance recovery for patients with spinal cord injuries.
How similar studies have performed: Previous research has shown promise in using similar approaches to mitigate inflammation and improve recovery in spinal cord injury models.
Where this research is happening
College Station, United States
- Texas A&m University — College Station, United States (Active)
Researchers
- Principal investigator: Mccreedy, Dylan a. — Texas A&m University
- Study coordinator: Mccreedy, Dylan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.