Using ketone esters to improve function in older adults with frailty
Official title: TAKEOFF: Targeting Aging with Ketone Ester in Older adults for Function in Frailty
Funded at Buck Institute for Research on Aging · NIH-10908375 · Data updated 2026-11-12
This study is looking at how a special energy source called ketone esters might help older adults who are feeling weak and less active, by improving their health and helping them stay independent as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $702,825 |
| NIH project number | 5R01AG081226-02 |
| Project ID | NIH-10908375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are experiencing frailty and related functional decline.
✕Less likely to help
Patients who are not older adults or those who do not exhibit signs of frailty may not benefit from this research.
What this research studies
This research investigates how ketone esters, which are compounds that provide an alternative energy source, can help improve the health and function of older adults experiencing frailty. The study aims to understand the biological mechanisms of aging and how ketone bodies can influence energy production and inflammation in the body. By focusing on older adults, the research seeks to address the complex issues of functional decline and increased vulnerability that come with aging. Participants will be involved in a multi-site trial that evaluates the effects of these compounds on their overall health and independence.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the quality of life and independence for older adults suffering from frailty.
How similar studies have gone: Previous research has shown promise in using ketone bodies for health benefits in aging, suggesting that this approach may be effective.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Newman, John C — Buck Institute for Research on Aging
- Study coordinator: Newman, John C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.