Using ketamine to help prevent chronic pain after surgery

Optimizing the use of ketamine to reduce chronic postsurgical pain

NIH-funded research New York University School of Medicine · NIH-10909245

This study is looking at how ketamine can help reduce pain and anxiety during and after breast surgery to prevent long-lasting pain afterwards, and it's designed for patients having mastectomy or breast-conserving surgery.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionNew York University School of Medicine NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10909245 on NIH RePORTER

What this research studies

This research investigates how ketamine can be used during and after surgery to prevent chronic postsurgical pain (CPSP), particularly in patients undergoing mastectomy or breast-conserving surgery. The study aims to assess the effectiveness of ketamine in reducing acute pain, anxiety, and depression, which are known risk factors for developing CPSP. By administering ketamine perioperatively, the researchers hope to enhance the body's natural pain control mechanisms and improve overall patient outcomes. The study is part of a larger initiative focused on improving pain management strategies.

Who could benefit from this research

Good fit: Ideal candidates for this research are patients scheduled for mastectomy or breast-conserving surgery who are at risk for developing chronic postsurgical pain.

Not a fit: Patients who are not undergoing surgery or those who do not experience significant postoperative pain may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the incidence of chronic pain in postoperative patients, leading to less reliance on opioids.

How similar studies have performed: There is strong clinical evidence supporting the use of ketamine for managing postsurgical pain, indicating that this approach has shown promise in previous studies.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Affective Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.