Using islet autoantibody profiles to tailor treatment for type 2 diabetes
Utilizing islet autoantibody signatures for precision medicine in type 2 diabetes
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10771154
This study is looking at how certain immune responses might affect type 2 diabetes and aims to find better ways to tailor treatments for people with diabetes based on their unique immune profiles.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10771154 on ClinicalTrials.gov |
What this research studies
This research investigates how islet autoimmunity affects type 2 diabetes by analyzing specific autoantibodies that may influence disease progression and complications. By employing advanced assays and statistical methods, the study aims to develop a precision medicine approach that can better classify diabetes phenotypes based on individual immune responses. Patients will be assessed for various autoantibodies, including those related to GAD65 and insulinoma antigen 2, to identify patterns that can guide personalized treatment strategies. The research utilizes data from the Look AHEAD trial, which focuses on lifestyle interventions in diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may have underlying islet autoimmunity.
Not a fit: Patients without type 2 diabetes or those whose diabetes is not influenced by islet autoimmunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with type 2 diabetes.
How similar studies have performed: Previous research has shown promise in using autoantibody profiles for precision medicine in diabetes, indicating that this approach could yield significant insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARUTHUR, NISA M — JOHNS HOPKINS UNIVERSITY
- Study coordinator: MARUTHUR, NISA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.