Using iron oxide nanoparticles to improve kidney preservation for transplants
Official title: Quantification of Iron Oxide Nanoparticles in Cryopreserved Kidneys with Longitudinally Detected Electron Paramagnetic Resonance
Funded at University of Minnesota · NIH-10901379 · Data updated 2026-11-12
This study is looking at a new way to help preserve kidneys for transplant by using tiny particles that can improve how long they can be stored and how well they work after being thawed, making it better for people who need a kidney transplant.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,943 |
| NIH project number | 1F30DK137445-01A1 |
| Project ID | NIH-10901379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals awaiting kidney transplants, particularly those whose potential donor kidneys may be at risk of being discarded due to preservation challenges.
✕Less likely to help
Patients who have already received a kidney transplant or those with conditions that preclude them from receiving a transplant may not benefit from this research.
What this research studies
This research investigates a method to enhance the preservation of kidneys for transplantation by using iron oxide nanoparticles (IONPs). These nanoparticles are infused into kidneys before they are cryopreserved at extremely low temperatures, allowing for longer storage times. The study focuses on developing a technique to monitor the distribution of these nanoparticles within the kidneys to ensure even warming during the re-thawing process, which is crucial for maintaining kidney viability. By employing a novel detection system called longitudinally detected electron paramagnetic resonance (LOD-EPR), the researchers aim to accurately track the concentration of IONPs in kidney tissues, potentially improving transplant outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of discarded kidneys and improve transplant success rates.
How similar studies have gone: While the use of iron oxide nanoparticles in kidney preservation has shown initial success in animal models, this specific approach using LOD-EPR for monitoring is novel and has not been extensively tested in human organs.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Kantesaria, Saurin — University of Minnesota
- Study coordinator: Kantesaria, Saurin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.