Using iron levels to understand inflammation in Alzheimer's disease
Iron as an Imaging Biomarker for Inflammation in AD
This study is looking at how iron in the brain might help us see signs of inflammation in Alzheimer's disease, using MRI scans to measure iron levels and understand how they relate to the disease's progression, which could help catch problems earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10538580 on NIH RePORTER |
What this research studies
This research investigates the role of iron as a potential imaging biomarker for inflammation in Alzheimer's disease (AD). It aims to measure iron levels in the brain using MRI technology, which could provide insights into the inflammatory processes associated with AD. By examining post-mortem brain tissue alongside MRI results, the study seeks to establish a connection between iron-containing microglia and the progression of AD. This approach may allow for earlier detection of inflammation before significant memory impairment occurs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and improved treatment strategies for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using imaging techniques to study brain inflammation, making this approach a potentially valuable advancement in Alzheimer's research.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Zeineh, Michael M — Stanford University
- Study coordinator: Zeineh, Michael M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.