Using intermittent hypoxia training to improve cognitive function in older adults with mild cognitive impairment
Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment
This study is exploring a new method called intermittent hypoxia training to see if it can help improve thinking skills in older adults with mild cognitive impairment, which can sometimes lead to Alzheimer's disease. Over eight weeks, participants will experience short periods of low oxygen to boost blood flow to the brain and support brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project ID | NIH-10862548 on NIH RePORTER |
What this research studies
This research investigates an innovative approach called intermittent hypoxia training (IHT) to enhance cognitive function in older adults experiencing mild cognitive impairment, a condition that can lead to Alzheimer's disease. Participants will undergo an 8-week program involving brief, controlled periods of low oxygen exposure, which aims to improve blood flow to the brain and promote neuroprotection. The study will assess the safety and effectiveness of this training in potentially reversing cognitive decline. By focusing on optimizing cerebral circulation, the research hopes to mobilize protective factors that support brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with amnestic mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or other severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option to slow or reverse cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results with intermittent hypoxia training in enhancing neuroprotection and cognitive function, suggesting potential for success in this novel application.
Where this research is happening
Fort Worth, United States
- University of North Texas Hlth Sci Ctr — Fort Worth, United States (Active)
Researchers
- Principal investigator: Shi, Xiangrong — University of North Texas Hlth Sci Ctr
- Study coordinator: Shi, Xiangrong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.