Using injectable hydrogels to improve neuron therapy for spinal cord injuries
Official title: Injectable hydrogels for hiPSC-neuron therapy of spinal cord injury
Funded at Stanford University · NIH-11117151 · Data updated 2026-11-12
This study is testing a special gel that helps protect and support nerve cells made from stem cells, aiming to improve recovery for people with spinal cord injuries, especially in the neck area.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $168,296 |
| NIH project number | 5K01EB033870-02 |
| Project ID | NIH-11117151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cervical spinal cord injuries who are seeking innovative treatment options.
✕Less likely to help
Patients with spinal cord injuries at other anatomical sites or those who do not qualify for cell transplantation therapies may not benefit from this research.
What this research studies
This research focuses on developing a specialized injectable hydrogel designed to enhance the survival and integration of human induced pluripotent stem cell-derived neurons (hiPSC-neurons) in patients with spinal cord injuries. The approach involves encapsulating these neurons within the hydrogel to protect them during injection and releasing growth factors over time to create a supportive environment for cell survival. By targeting cervical spinal cord injuries, the research aims to address a significant gap in current regenerative therapies, which often fail due to poor cell viability. The study will evaluate the effectiveness of this biomaterial in preclinical models before considering potential applications in human patients.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for spinal cord injuries, potentially restoring function and quality of life for affected patients.
How similar studies have gone: Previous research has shown promise in using injectable hydrogels for cell transplantation, indicating potential for success in this novel application.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Doulames, Vanessa Madelyn — Stanford University
- Study coordinator: Doulames, Vanessa Madelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.