Using inhaled statins to relax airway muscles in asthma patients
Reducing Airway Smooth Muscle Tone Using Inhaled Statins
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10846811
This study is looking at how inhaled statins might help relax the muscles in your airways during asthma attacks, aiming to find a better way to ease your breathing when you need it most.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10846811 on ClinicalTrials.gov |
What this research studies
This research investigates the use of inhaled statins to directly target and relax airway smooth muscle during asthma exacerbations. Current asthma treatments often focus on blocking or activating receptors, which can be complex and less effective. Instead, this study aims to disrupt the contractile mechanisms of airway smooth muscle using statins, specifically examining their effects on muscle contraction in human lung cells. By understanding how statins can inhibit muscle contraction, the research hopes to provide a more effective treatment option for asthma patients experiencing breathlessness.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from asthma and experience frequent exacerbations.
Not a fit: Patients who do not have asthma or those who are not responsive to inhaled medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new and more effective treatment for asthma that alleviates symptoms of breathlessness.
How similar studies have performed: While the use of statins for asthma treatment is a novel approach, there is emerging evidence suggesting that targeting the contractile apparatus of airway smooth muscle could be beneficial.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZEKI, AMIR A. — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ZEKI, AMIR A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.