Using inhaled Pitavastatin to treat asthma
Inhaled Pitavastatin for the Treatment of Asthma: A New Therapeutic Paradigm
This study is exploring a new way to help people with asthma by using an inhaled version of a medication called Pitavastatin, which could improve breathing and reduce asthma attacks.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11120772 on NIH RePORTER |
What this research studies
This research investigates the use of inhaled Pitavastatin as a new treatment option for asthma, aiming to improve symptom control and reduce acute exacerbations. The study focuses on developing a proprietary formulation of Pitavastatin for inhalation, as previous oral forms have shown poor effectiveness in reaching the airways. By testing this formulation in a human-relevant asthma model using non-human primates, the researchers hope to gather critical data before moving on to human clinical trials. This innovative approach seeks to leverage the anti-inflammatory properties of statins to provide better asthma management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who suffer from asthma and have not achieved adequate control with current therapies.
Not a fit: Patients with asthma who are not responsive to inhaled therapies or those with contraindications to statins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective inhaled therapy for asthma, improving quality of life for patients.
How similar studies have performed: While the use of statins for asthma treatment has shown promise in pre-clinical models, this inhaled delivery method is a novel approach that has not yet been tested in human populations.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Zeki, Amir a. — University of California at Davis
- Study coordinator: Zeki, Amir a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.